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An Interdisciplinary Journal on Sexual Health

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From Fertilization to 
Adult Sexual Behavior 

Milton Diamond, Teresa Binstock and
James V. Kohl

 Abstract:  Research has established the broad mammalian developmental plan that genes on the sex chromosomes influence gonad development which determines gonadal hormone production (or its absence) leading to modification of the genitalia and simultaneously biasing the nervous system to organize adult sexual behavior. This might be considered the “gonad to hormones to behavior” model. It is clear, however, that although this model generally works well it is incomplete. The model does not account for behavioral influences attributed to the environment or to genetic but nongonadal or hormonal factors. In this essay we probe those areas of sexual development that are neither differentiated by hormones nor activated by them. The concept of the environment used for our discussion is very broad; it incorporates considerations of both the molar and the molecular levels. The general sense of the word “environment” as something exterior to the person is retained, even if that something influences intraperson processes. In addition, we focus directly on molecular events themselves. Here the “environment” involved can be that within a DNA segment. We also expand the notion of “biologically based sex differences.” Although many, and perhaps most, important sex differences arise from gonadal and hormonal development, also important are sex differences which are neither gonadal nor hormonal. All these factors affect the internal workings of the individual and intervene in structuring how the social environment might or might not modify sexual behavior. This discourse calls attention to features that are central to the so-called nature-nurture discussion.

KEY WORDS:  Adult, Sexual Behavior, Fertilization, nurture, development

SexuS Journal ● 2018 ● 3 (10): 743-772


Adler, B. K., and Hajduk, S.L. (1994). Mechanisms and origins of RNA editing. Curr. Opin. Genet. Dev. 4, 316-322.

Anderson, D. K., Fleming, D. E., Rhees, R. W., and Kinghorn, E. (1986). Relationships between sexual activity, plasma testosterone, and the volume of the sexually dimorphic nucleus of the preoptic area in prenatally stressed and non-stressed rats. Brain Res. 370, 1-10.

Anderson, D. K., Rhees, R. W., and Fleming, D. E. (1985). Effects of prenatal stress on differentiation of the sexually dimorphic nucleus of the preoptic area (SDN-POA) of the rat brainBrain Res. 332, 113-118.

Artola, A., and Singer, W. (1993). Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation. Trends Neurosci. 16, 480-487.

Bailey, J. M., and Pillard, R. C. (1991). A genetic study of male sexual orientation. Arch. Gen. Psychiat. 48, 1089-1096.

Bailey, J. M., and Pillard, R. C. (1995). Genetics of human sexual orientation. Annu. Rev. Sex Res. 6, 126-150.

Bailey, J. M., Willerman, L., and Parks, C. (1991). A test of the maternal stress theory of human male homosexuality.Arch. Sex. Behav. 20, 277-293.

Bartoshuk, L. M., and Beauchamp, G. K. (1994). Chemical Senses. Annu. Rev. Psychol. 45, 419-449.

Baulieu, E. E., and Robel, P. (1990). Neurosteroids: A new brain function? J. Steroid Biochem. Mol. Biol. 37, 395-403.

Bennett, C. P., Docherty, Z., Robb, S. A., Ramani, P., Hawkins, J. R., and Grant, D. (1993). Deletion 9p and sex reversal. J. Med. Genet. 30, 518-520.

Berliner, D. L. (1994). Fragrance compositions containing human pheromones. United States Patent Office No. 5, 278,141.

Berliner, D. L., Monti-Bloch, L., Jennings-White, C., and Diaz-Sanchez, V. (1996). Functionality of the human vomeronasal organ (VNO): Evidence for steroid receptors. J. Steroid Biochem. Mol. Biol. 58, 259-265.

Bianchi, D. W., Zickwolf, C. K., Weil, G. J., Sylvester, S., and DeMaria, M. A. (1996). Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc. Natl. Acad. Sci. USA 93, 705-708.

Binstock, T. C. (1996). A series of postings stating: Immunological hypothesis of sexual and gender orientations.Bionet. Neuroscience; (bionet.neurosciences) (17 March).

Black, A. H., and Prokasy, W. F. (Eds.). (1972). Classical Conditioning II: Current Research and Theory. Appleton-Century-Crofts, New York.

Blanchard, R., and Bogaert, A. F. (1996). Homosexuality in men and number of older brothers. Am. J. Psychiat. 153, 27-31.

Blanchard, R., and Zucker, K. J. (1994). Reanalysis of Bell, Weinberg, and Hammersmith’s data on birth order, sibling sex ratio, and parental age in homosexual men. Am. J. Psychiat. 151, 1375-1376.

Bobrow, N. A., Money, J., and Lewis, V. J. (1971). Delayed puberty, eroticism and sense of smell: A psychological study of hypogonadotropinism, osmatic and anosmatic (Kallmann’s syndrome). Arch. Sex. Behav. 1, 329-344.

Boggs, B. A., and Chinault, A. C. (1994). Analysis of replication timing properties of human X-chromosomal loci by fluorescence in situ hybridization. Proc. Natl. Acad. Sci. USA 91, 6083-6087.

Brand, T., Houtsmuller, E. J., and Slob, A. K. (1993). Neonatal programming of adult partner preference in male rats. InM. Haug, R. E. Whalen, C. Axon, and K. L. Olsen (Eds.), The Development of Sex Differences and Similarities in Behaviour, pp. 33-49. Kluwer Academic Publishers, Dordrecht.

Breedlove, S. M. (1994). Sexual differentiation of the human nervous system. Annu. Rev. Psychol. 45, 389-418.

Brook, J. D. (1993). Retreat of the triplet repeat? Nature Genet. 3e, 279-289.

Buck, L., and Axel, R. (1991). A novel multi-gene family may encode odorant receptors: A molecular basis for odor recognition. Cell 65, 175-187.

Bull, J. J. (1983). Evolution of Sex Determining Mechanisms. Benjamin/Cummings Publishing, Menlo Park.

Burgoyne, P. S., Thornhill, A. R., Boudrean, S. K., Darling, S. M., Bishop, C. E., and Evans, E. P. (1995.). The genetic basis of XX-XY differences present before gonadal sex differentiation in the mouse. Phil. Trans. Royal Soc. London.-.Ser. B: Biol. Sci. 350, 253-60.

Butler, M. G., Pratesi, R., Watson, M. S., Breg, W. R., and Singh, D. N. (1993). Anthropometric and craniofacial patterns in mentally retarded males with emphasis on the fragile X syndrome. Clin. Genet. 44, 129-138.

Caviness, V. S. J. (1992). Kallmann’s syndrome—Beyond “migration” N. Engl. J. Med. 326, 1775-1777. [Ed. comment]

Clemson, C. M., and Lawrence, J. B. (1996). Multifunctional compartments in the nucleus: Insights from DNA and RNA localization. J. Cell. Biochem. 62, 181-190.

Compagnone, N. A., Bulfone, A., Rubenstein, J. L., and Mellon, S. H. (1995a). Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis. Endocrinology 136, 2689-2696.

Compagnone, N. A., Bulfone, A., Rubenstein, J. L., and Mellon, S. H. (1995b). Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system. Endocrinology 136e, 5212-5223.

Conn, P. M., and Crowley, W. F., Jr. (1991). Gonadotropin-releasing hormone and its analogues. N. Engl. J. Med. 324, 93-104.

Crowley, W. F. J., and Jameson, J. L. (1992). Clinical counterpoint: Gonadotropin-releasing hormone deficiency: Perspectives from clinical investigation. Endocrinol. Rev. 13, 635-640.

D’Esposito, M., Ciccodicola, A., Gianfrancesco, F., Esposito, T., Flagiello, L., Mazzarella, R., Schiessinger, D., and D’Urso, M. (1996). A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation. Nature Genet. 13, 227-229.

Dahlöf, L.-G., Hard, E., and Larsson, K. (1977). Influence of maternal stress on the development of offspring sexual behaviour. Anim. Behav. 25, 958-963.

de Bono, M., Zarkower, D., and Hodgkin, J., (1995). Dominant feminizing mutations implicate protein-protein interactions as the main mode of regulation of the nematode sex-determining gene tra-l. Genes Dev. 9, 155-167.

Desor, J. A., Miller, O., and Turner, R. E. (1973). Taste in acceptance of sugars by human newborns. J. Comp. Physiol. Psych. 84, 496-501.

Desor, J. A., Miller, O., and Turner, R. E. (1977). Preference for sweet in humans: Infants, children and adults. In J. M. Weiffenbach (Ed.), Taste and Development: The Genesis of Sweet Preference. US. Government Printing Office, Washington, DC.

Diamond, M. (1965). A critical evaluation of the ontogeny of human sexual behavior. Quart. Rev. Biol. 40, 147-175.

Diamond, M. (1979). Sexual identity and sex roles. In V. Bullough (Ed.), The Frontiers of Sex Research, pp. 33-56. Prometheus, Buffalo, NY.

Diamond, M. (1995). Biological aspects of sexual orientation and identity. In L. Diamant and R. McAnulty (Eds.), The Psychology of Sexual Orientation, Behavior and Identity: A Handbook, pp. 45-80. Greenwood Press, Westport, CT.

Diamond, M. (1996). Self-testing among transsexuals: A check on sexual identity. J. Psych. Hum. Sex. 8, 61-82.

Diamond, M. (1997a). Self-testing: A check on sexual levels. In B. Bullough and V. L. Bullough (Eds.), Cross Dressing and Transgenderism. Prometheus, Buffalo, NY, in press.

Diamond, M. (1997b). Sexual identity and sexual orientation in children with traumatized or ambiguous genitalia. J. Sex Res., 34(2), in press.

Diamond, M., and Henderson, M. (1980). Oral-genital behavior in hamster. Behav. Neur. Biol. 28, 1-8.

Diamond, M., Llacuna, A., and Wong, C. (1973). Sex behavior after neonatal progesterone, testosterone, estrogen or antiandrogens. Horm. Behav. 4, 73-88.

Diamond, M., and Sigmundson, K (1997). Sex reassignment at birth: A long term review and clinical implications. Arch. Ped. Adolesc. Med., 151, in press.

Diamond, M. C. (1984). Age, sex, and environmental influences. In N. Geschwind and A. M. Galaburda (Eds.), Cerebral Dominance: The Biological Foundations, pp. 134-146. Harvard Univ. Press, Cambridge, MA.

Dizzino, C., Whitney, G., and Nyby, J. (1978). Ultrasonic vocalizations by male mice (Mus musculus) to female sex pheromone: Experiential determinants. Behav. Biol. 22, 104-113.

Dörner, G., Geier, T., Ahrens, L., Krell, L., Munx, G., Sieler, H., Kittner, E., and Muller, H. (1980). Prenatal Stress as a possible etiological factor in homosexuality in human males. Endokrinologie 75, 365-368.

Dörner, G., Schenk, B., Schmiedel, B., and Ahrens, L (1983). Stressful events in prenatal life of bi- and homosexual men. Exp. Clin. Endocrinol. 81, 83-87.

Dorries, K. M., Schmidt, H. J., Beauchamp, G. K, and Wysocki, C. J. (1989). Changes in sensitivity to the odor of androstenone during adolescence. Dev. Psychobiol. 22, 423-435.

Driscoll, D. J., Waters, M. F., Williams, C. A., Zori, R. T., Glenn, C. C., Avidano, K M., and Nicholls, R. D. (1992). A DNA methylation imprint, determined by the sex of the parent, distinguishes the Angelman and Prader-Willi syndromes.Genomics 13, 917-924.

Elias, A. N., and Valenta, L J. (1992). Are all males equal? Anatomic and functional basis for sexual orientation in males. Med. Hypoth. 39, 85-87.

Ellis, L., Ames, M. A., Peckham, W., and Burke, D. (1988). Sexual orientation of human offspring may be altered by severe maternal stress during pregnancy. J. Sex Res. 25, 152-157.

Engen, T. (1982). The Perception of Odors. Academic Press, New York.

Fiddler, M., Abdel-Rahman, B., Rappolee, D. A., and Pergament, E. (1995). Expression of SRY transcripts in preimplantation human embryos. Am. J. Med. Genet. 55, 80-84.

Fisher, E. M., Beer-Romero, P., Brown, L G., Ridley, A., McNeil, J. A., Lawrence, J. B., Willard, H. F., Bieber, F. R., and Page, D. C. (1990). Homologous ribosomal protein genes on the human X and Y chromosomes: Escape from X inactivation and possible implications for Turner syndrome. Cell 63, 1205-1218.

Foucault, M. (1980; originally published 1964). The History of Sexuality: An Introduction, Vol. 1, U.S. ed. Viking. New York.

Freud, S. (1953; originally published 1905). Three Essays on the Theory of Sexuality. Standard edition 7. Hogarth Press, London.

Freud, S. (1971; originally published 1920). A General Introduction to Psychoanalysis. Pocket Books, New York.

Gagnon, J. H., and Simon, W. (1973). Sexual Conduct: The Social Origins of Human Sexuality. Aldine, Chicago.

Gandelman, R. (1992). The Psychobiology of Behavioral Development. Oxford Univ. Press, New York.

Ge, H., Zuo, P., and Manley, J. L. (1991). Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell 66, 373-382.

Genazzani, A. R., Palumbo, M. A., de Micheroux, A. A., Artini, P. C., Criscuolo, M., Ficarra, G., Guo, A. L., Benelli, A., Bertolini, A., Petraglia, F., and Purdy, R. H. (1995). Evidence for a role for the neurosteroid allopregnanolone in the modulation of reproductive function in female rats. Eur. J. Endocrinol. 133, 375-380.

Gerendai, I., Csaba, Z., Voko, Z., and Csernus, V. (1995). Involvement of a direct neural mechanism in the control of gonadal functions. J. Steroid Biochem. Mol. Biol. 53, 299-305.

Gilbert, A. N., Yamazaki, K., Beauchamp, G. K., and Thomas, L. (1996). Olfactory discrimination of mouse strains(Mus musculus) and major histocompatibility types by humans (Homo sapiens). J. Comp. Psych. 100, 262-265.

Goldfoot, D. A., Wallen, K., Neff, D. A., McBrair, M. C., and Goy, R. W. (1984). Social influences upon the display of sexually dimorphic behavior in rhesus monkeys: Isosexual rearing. Arch. Sex. Behav. 13, 395-406.

Goy, R. W., Bercovitch, F. B.. and McBrair, M. C. (1988). Behavioral masculinization is independent of genital masculinization in prenatally androgenized female rhesus macaques. Horm. Behav. 22, 552-571.

Goy, R. W., and McEwen, B. S. (1980). Sexual Differentiation of the Brain. MIT Press, Cambridge, MA.

Goy, R. W., and Wallen, K. (1979). Experiential variables influencing play, foot-clasp mounting and adult sexual competence in male rhesus monkeys. Psychoneuroendocrinology 4, 1-12.

Graves, J. A. (1995). The evolution of mammalian sex chromosomes and the origin of sex determining genes. Philos. Trans. Royal Soc. London.-.Ser. B Biol. Sci. 350, 305-311.

Green, M. R. (1991). Biochemical mechanisms of constitutive and regulated pre-mRNA splicing. Annu. Rev. Cell Biol.7, 559-599.

Griffith, M. K, and Williams, G. L. (1996). Roles of maternal vision and olfaction in suckling-mediated inhibition of luteinizing hormone secretion, expression of maternal selectivity, and lactational performance of beef cows. Biol. Reprod. 54, 761-768.

Grisham, W., Kerchner, M., and Ward, I. L. (1991). Prenatal stress alters sexually dimorphic nuclei in the spinal cord of male rats. Brain Res. 551, 126-131.

Gruendel, A. D., and Arnold, W. J. (1969). Effects of early social deprivation on reproductive behavior of male rats. J. Comp. Physiol. Psych. 67, 123-128.

Gunter, L. M. (1963). Psychopathology and stress in the life experience of mothers of premature infants. Am. J. Obstet. Gynecol. 86, 333-340.

Guthrie, K. M., Anderson, A. J., Leon, M., and Gall, C. (1993). Odor-induced increases in c-fos mRNA expression reveal an anatomical “unit” for odor processing in the olfactory bulb. Proc. Natl. Acad. Sci. USA 90, 3329-3333.

Gutzke, W. H. N., and Paukstis, G. L. (1984). A low temperature threshold for sexual differentiation in the painted turtle,Chrysemys picta. Copeia 1984, 546-547.

Hamer, D., and Copeland, P. (1994). The Science of Desire: The Search for the Gay Gene and the Biology Behavior.Simon & Schuster, New York.

Hamer, D. H., Hu, S., Magnuson, V. L., Hu, N., and Pattatucci, A. M. L. (1993). A linkage between DNA markers on the X chromosome and male sexual orientation. Science 261, 321-327.

Hansen, R. S., Canfield, T. K, and Gartler, S. M. (1995). Reverse replication timing for the XIST gene in human fibroblasts. Hum. Mol. Genet. 4, 813-820.

Hard, E., and Larsson, K. (1968). Dependence of adult mating behavior in male rats on the presence of litter mates in infancy. Brain, Behav. Evol. 1, 405-419.

Harlow, H. (1962). The heterosexual affectional system in monkeys. Amer. Psychol. 17, 1-9.

Harlow, H. (1965). Sexual behavior in the Rhesus monkey. In F. A. Beach (Ed.), Sex and Behavior, pp. 234-259-265. Wiley, New York.

Harlow, H. (1971). Learning to Love. Albion, San Francisco.

Harrison, K. B. (1989). X-chromosome inactivation in the human cytotrophoblast. Cytogen. Cell Genet. 52, 37-41.

Harvey, P. W., and Chevins, P. F. D. (1984). Crowding or ACTH treatment of pregnant mice affects adult copulatory behavior of male offspring. Horm. Behav. 18, 101-110.

Harvey, P. W., and Chevins, P. F. D. (1985). Crowding pregnant mice affects attack and threat behavior of male offspring. Horm. Behav. 19, 86-97.

Hawkins, R. D., Kandel, E. R., and Siegelbaum, S. A. (1993). Learning to modulate transmitter release: Themes and variations in synaptic plasticity. Anne. Rev. Neurosci. 16, 625-665.

Henderson, M. E. (1976). Evidence for a male menstrual temperature cycle and synchrony with the female menstrual cycle. New Zealand Med. J. 84, 164. [Abstract]

Hepper, P. G. (1987). The amniotic fluid: An important priming role in kin recognition. Anim. Behav. 35, 1343-1346.

Hu, S., Pattatucci, A. M. L., Patterson, C., Li, L., Fulker, D. W., Cherny, S. S., Kruglyak, L., and Hamer, D. H. (1995). Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nature Genet. 11, 248-256.

Hurst, L. D., McVean, C., and Moore, T. (1996). Imprinted genes have few and small introns. Nature Genet. 12, 234-237.

Jakacki, R. I., Kelch, R. P., Sauder, S. E., Lloyd, J. S., Hopwood, N. J., and Marshall, J. C. (1982). Developmental changes in neuroendocrine regulation of gonadotropin secretion in gonadal dysgenesis.  J. Clin. Endocrinol. Metab. 55, 453-458.

Jennings-White, C. (1995). Perfumery and the sixth sense. Perfumer & Flavorist 20, 1-7.

Jost, A. (1953). Problems of fetal endocrinology: The gonadal and hypophyseal hormones. Recent Progr. Horm. Res. 8, 379-418.

Jost, A. (1961). The role of fetal hormones in prenatal development. Harvey Lectures 55, 201 -226.

Juraska, J. M. (1990). The structure of the rat cerebral cortex: Effects of gender and the environment. In B. Kolb and R. C. Tees (Eds.), The cerebral cortex of the rat, pp. 483-505. MIT Press, Cambridge, MA.

Juraska, J. M., Kopick, J., Washburne, D. L., and Perry, D. L. (1988). Neonatal castration of male rats affects the dendritic response to differential environments in hippocampal dentate granule neurons. Psychobiology 16, 406-410.

Jütte, A. (1996). Cognitive and physiological responses of men to female pheromones, 13th International Conference of the International Society for Human Ethology, August 5-10, Vienna, Austria.

Kabbadj, K., el-Etr. M., Baulieu, E. E., and Robel, P. (1993). Pregnenolone metabolism in rodent embryonic neurons and astrocytes. GLIA 7, 170-175.

Kavaliers, M., and Kinsella, D. M. (1995). Male preference for the odors of estrous female mice is reduced by the neurosteroid pregnenolone sulfate. Brain Res. 682, 222-226.

Kerchner, M., and Ward, I. L. (1992). SDN-MPOA volume in male rats is decreased by prenatal stress but is not related to ejaculatory behavior. Brain Res. 581, 244-251.

Kitzinger, C., and Wilkinson, S. (1995). Transitions from heterosexuality to lesbianism: The discursive production of lesbian identities. Dev. Psychol. 31, 95-104.

Kohl, J. V. (1996). Human pheromones: Mammalian olfactory, genetic, neuronal, hormonal and behavioral reciprocity, and human sexuality. Advances in Human Behavior and Evolution. http://psych.lmu.edu/ahbe.htm (May 16, 1996).

Kohl, J. V., and Francoeur, R. T. (1995). The Scent of Eros: Mysteries of Odor in Human Sexuality. Continuum, New York.

Korsrud, F. R., and Brandtzaeg, P. (1983). Immunology of human nasal mucosa. Rhinology 21, 203-212.

Kwok, C., Tyler-Smith, C., Mendonca, B. B., Hughes, I., Berkovitz, G. D., Goodfellow, P. N., and Hawkins, J. R.(1996). Mutation analysis of the 2kb 5' to SRY in XY females and XY intersex subjects. J. Med. Genet. 33, 465-468.

Lau, Y. F., and Chan, K. M. (1989). The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. Am. J. Hum. Genet. 45, 942-952.

Lawrence, S., Collins, A., Keats, B. J., Hulten, M., and Morton, N. E. (1993). Integration of gene maps: Chromosome 21. Proc. Natl. Acad. Sci. LISA 90, 7210-7214.

LeMagnen, J. (1982). Olfacto-endocrine relationships: Past and future lines of investigations. In W. Breipohl (Ed.),Olfaction and Endocrine Regulation. pp. 1-10. IRL Press Ltd., London.

Liou, J. D., Pao, C. C., Hor, J. J., and Kao, S. M. (1993). Fetal cells in the maternal circulation during first trimester in pregnancies. Hum. Genet. 92, 309-311.

Lorenz, K. (1935). Der Kumpan in der Unwelt des Vogels. J. für Ornithologies 83, 137-213.

Loumaye, E., Thorner, J., and Cart, K. J. (1982). Yeast mating pheromone activates mammalian gonadotrophs: Evolutionary conservation of a reproductive hormone? Science 218, 1323-1325.

Machin, C. A. (1996). Some causes of genotypic and phenotypic discordance in monozygotic twin pairs. Am. J. Med. Genet. 61, 216-228.

MacLean, P. (1985). Brain evolution relating to family, play, and the separation call. Arch. Gen. Psychiat. 42, 405-417.

Manders, E. M. M., Stap, J., Strackee, J., van Driel, R., and Aten, J. A. (1996). Dynamic behavior of DNA replication domains. Exp. Cell Res. 226, 328-335.

McClintock, M. (1971). Menstrual synchrony and suppression. Nature 229, 244-246.

McEwen, B. S. (1981). Neural gonadal steroid actions. Science 211, 1303-1311.

McEwen, B. S. (1983). Gonadal steroid influences on brain development and sexual differentiation. In R. O. Greep (Ed.), Reproductive Physiology IV, International Review of Physiology, Vol. 27, pp. 99-145. University Park Press, Baltimore.

Mellon, S. H., and Deschepper, C. F. (1993) Neurosteroid biosynthesis: Genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res. 629, 283-292.

Mennella, J. A. (1995). Mother’s milk: A medium for early flavor experiences. J. Hum. Lactation 11, 39-45.

Mennella, J. A. (1996). The flavor world of infants. Pediatr. Basics 77(Summer), 2-8.

Meredith, M., and Howard, C., (1992). Intracerebroventricular LHRH relieves behavioral deficits due to vomeronasal organ removal. Brain Res. Bull. 29, 75-79.

Meredith, M., and Fernandez-Fewell, C. (1994). Vomeronasal system, LHRH, and sex behaviour.Psychoneuroendocrinology 19, 657-672.

Miley, W. M. (1983). Prenatal stress suppresses hunger-induced rat-pup killing in Long-Evans rats. Bull. Psychon. Soc.21, 495-497.

Monk, M. (1995). Epigenetic programming of differential gene expression in development and evolution. Dev. Genet. 17, 188-197.

Moore, C. L. (1984). Maternal contribution to the development of masculine sexual behavior in laboratory rats. Dev. Psychobiol. 17, 347-356.

Moore, C. L. (1992). The role of maternal stimulation in the development of sexual behavior and its neural basis.Ann.NY Acad. Sci.:Dev. Psychobiol. 662, 160-177.

Moore, C. L. (1995). Maternal contributions to mammalian reproductive development and the divergences of males and females. Adv. Study Behav. 24, 47-118.

Moore, C. L., and Morelli, G. A. (1979). Mother rats interact differently with male and female offspring. J. Comp. Physiol. Psych. 93, 677-684.

Morahan, G., Huang D., Tait, B. D., Colman, P. G., and Harrison, L. C. (1996) Markers of distal chromosome 2q linked to insulin- dependent diabetes mellitus. Science 272, 1811-1813.

Moran, D. T., Monti-Block, L., Stensaas, L. J., and Berliner, D. L. (1995). Structure and function of the human vomeronasal organ. In R. L. Doty (Ed.), Handbook of Olfaction and Gustation, pp.793-820. Dekker, New York.

Murray, J. C., Buetow, K. H., Weber, J. L., Ludwigsen, S., Scherpbier-Heddema, T., Manion, F., Quillen, J., Sheffield, V. C., Sunden, S., and Duyk, G. M. (1994). A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC). Science 265, 2049-2054.

North, M., Sargent, C., O’Brien, J., Taylor, K., Wolfe, J., Affara, N. A., and Ferguson-Smith, M. A. (1991). Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. Nucleic Acids Res. 19, 2579-2586.

Ober, C., Weitkamp, L. R., Elias, S., and Kostyu, D. D. (1993). Maternally inherited HLA haplotypes influence mate choice in human isolate. Am. J. Hum. Genet. 53, Abstract No. 206.

Page, D. C., Disteche, C. M., Simpson, E. M., De La Chapelle, A., Andersson, M., Alitalo, T., Brown, L. C., Green, P., and Akots, G. (1990). Chromosomal localization of ZFX-A human gene that escapes X inactivation-and its murine homologs. Genomics 7, 37-46.

Parkhurst, S. M., and Meneely, P. M. (1994). Sex determination and dosage compensation: Lessons from flies and worms. Science 264, 924-932.

Perkins, A., and Fitzgerald, J. A. (1992). Luteinizing hormone, testosterone, and behavioral response of male-oriented rams to estrous ewes and rams. J. Anim. Sci. 70, 1787-1794.

Persky, H., Lief, H. I., Strauss, D., Miller, W. R., and O’Brien, C. P. (1978). Plasma testosterone level and sexual behavior of couples. Arch. Sex. Behav. 7, 157-173.

Pfaus, J. G., Jakob, A., Kleopoulos, S. P., Gibbs, R. B., and Pfaff, D. W. (1994). Sexual stimulation induces fos immunoreactivity within GnRH neurons of the female rat preoptic area: Interactions with steroid hormones.Neuroendocrinology 60, 283-290.

Phoenix, C. H., Goy, R. W., Gerall, A. A., and Young, W. C. (1959). Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65, 369-382.

Pollard, I. (1996). Preconceptual programming and sexual orientation: A hypothesis. J. Theor. Biol. 179, 269-273.

Razin, A., and Shemer, R. (1995). DNA methylation in early development. Hum. Mol. Genet. 4, 1751-1755. [Spec. No.]

Reik, W. (1989). Genomic imprinting and genetic disorders in man. Trends Genet. 5, 331-336.

Rhees, R. W., and Fleming, D. E. (1981). Effects of malnutrition, maternal stress, or ACTH injection during pregnancy on sexual behavior of male offspring. Physiol. Behav. 27, 879-882.

Roselli, C. E. (1995). Subcellular localization and kinetic properties of aromatase activity in rat brain. J. Steroid Biochem. Mol. Biol. 52, 469-477.

Ross, R., Losey, G., and Diamond, M. (1983). Sex change in a coral-reef fish: Dependence of stimulation and inhibition on relative size. Science 221, 574-575.

Runge, K. W., and Zakian, V. A. (1996). TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 3094-3105.

Sackett, G. P., Holm, R., and Ruppenthal, C. C. (1976). Social isolation rearing: Species differences in behavior of Macaque monkeys. Dev. Psychol. 10, 282-288.

Sagar, S. M., Sharp, F. R., and Curran, T. (1988). Expression of c-los protein in brain: Metabolic mapping at the cellular level. Science 240, 1328-1330.

Sanders, S. A., and Reinisch, J. M. (1990). Biological and social influences on the endocrinology of puberty: Some additional comments. In J. Bancroft and J. M. Reinisch (Eds.), Adolescence and Puberty, pp. 50-62. Oxford Univ. Press, New York.

Saunders, W. S., Chue, C., Goebl, M., Craig, C., Clark, R. F., Powers, J. A., Eissenberg, J. C., Elgin, S. C., Rothfield, N. F., and Earnshaw, W. C. (1993). Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity. J. Cell Sci. 104, 573-582.

Schafer, A. J., Dominguez-Steglich, M. A., Guioli, S., Kwok, C., Weller, P. A., Stevanovic, M., Weissenbach, J., Mansour, S., Young, I. D., Goodfellow, P. N., Brook, J. D., and Foster, J. W. (1995). The role of SOX9 in autosomal sex reversal and campomelic dysplasia. Philos.Trans. Royal Soc. London.-Ser. B: Biol. Sci. 350, 271-277.

Schmidt, C., and Clement, U. (1988). Does peace prevent homosexuality? International Academyof Sex Research.Minneapolis, Minnesota. (16-20 August.)

Schneider-Gadicke, A., Beer-Romero, P., Brown, L. C., Mardon, C., Luoh, S. W., and Page, D. C. (1989). Putative transcription activator with alternative isoforms encoded by human ZFX gene. Nature 342, 708 -711.

Schwanzel-Fukuda, M., Bick, D., and Pfaff, D. W. (1989). Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome. Mol. Brain Res. 6, 311-326.

Schwanzel-Fukuda, M., Crossin, K. L., Pfaff, D. W., Bouloux, P. M. G., Hardelin, J.-P., and Petit, C. (1996). Migration of luteinizing hormone-releasing hormone (LHRH) neurons in early human embryos. J. Comp. Neurol. 366, 547-557.

Segovia, S., and Guillamón, A. (1993). Sexual dimorphism in the vomeronasal pathway and sex differences in reproductive behaviors. Brain Res. Rev. 18, 51-74.

Shiroishi, T., Sagai, T., Hanzawa, N., Gotoh, H., and Moriwaki, K. (1991). Genetic control of sex-dependent meiotic recombination in the major histocompatibility complex of the mouse. EMBO J. 10, 681-686.

Simpson, E. (1991). Minor histocompatibility antigens. Immunol. Lett. 29, 9-14.

Singh, D. (1993). Adaptive significance of female physical attractiveness: Role of waist-to-hip ratio. J. Personal. Soc. Psychol. 65, 293-307.

Singh, D. (1995). Human body shape and mate choice (abstract), International Behavioral Development Symposium: Biological Basis Sexual Orientation and Sex-Typical Behavior, pp. 71. Minot, N.D. (May 25- 27).

Singh, P. B., Miller, J. R., Pearce, J., Kothary, R., Burton, R. D., Paro, R., James, T. C., and Gaunt, S. J. (1991). A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res.19, 789-794.

Smith, K. D., Young, K. E., Talbot, C. C., Jr., and Schmeckpeper, B. J. (1987). Repeated DNA of the human Y chromosome. Development 101 Suppl., 77-92.

Soumi, S. J. (1982). Abnormal behavior and primate models of psychopathology. In J. L. Forbes and J. E. King (Eds.),Primate Behavior. pp. 171-215. Academic Press, New York.

Stein, G. S., Stein, J. L., Lian, J. B., van Wijnen, A. J., and Montecino, M. (1996). Functional interrelationships between nuclear structure and transcriptional control: Contributions to regulation of cell cycle- and tissue-specific gene expression. J. Cell. Biochem. 62, 198-209.

Straub, R. E., Speer, M. C., Luo, Y., Rojas, K., Overhauser, J., Ott, J., and Gilliam, T. C. (1993). A microsatellite genetic linkage map of human chromosome. Genomics 15, 48-56.

Surani, M. A. (1991). Genomic imprinting: Developmental significance and molecular mechanism. Curr. Opin. Genet. Devel. 1, 241-246.

Thornhill, R., Gangestad, S. W., and Corner, R. (1995). Human female orgasm and mate fluctuating asymmetry. Anim. Behav. 50, 1601-1615.

Tjio, J. H., and Levan, A. (1956).The chromosome number of man. Hereditas 42, 1-6.

Tolman, E. C. (1932). Purposive Behavior in Animals and Men. Century, New York.

Tolle, T. R., Schadrack, J., and Zieglgänsberger, W. (Eds.). (1995). Immediate-Early Genes in the Central Nervous System. Springer, Berlin.

Trofatter, J. A., Long, K. R., Murrell, J. R., Stotler, C. J., Gusella, J. F., and Buckler, A. J. (1995). An expression-independent catalog of genes from human chromosome 22. Genome Res. 5, 214-224.

Turner, W. J. (1994). Comments on discordant monozygotic twinning in homosexuality. Arch. Sex. Behav. 23, 115-119.

Turner, W. J. (1995). Homosexuality, Type 1: An Xq28 phenomenon. Arch. Sex. Behav. 24, 109-134.

Van Toller, S., and Kendal-Reed, M. (1995). A possible semiotic role for odor in the protocognitive development of human infant behaviour: A speculative review. Brain Cogn. 29, 275-293.

Vandenbergh, J. C. (1994). Pheromones and mammalian reproduction. In E. Knobil and J. D. Neill (Eds.), The Physiology of Reproduction, Vol. 2, pp. 343-359. Raven Press, New York.

Vega-Matuszczyk, J., Fernandez-Guasti, A., and Larsson, K. (1988). Sexual orientation, proceptivity, and receptivity in the male rat as a function of neonatal hormonal manipulation. Horm. Behav. 22, 362-378.

vom Saal, F. S. (1983). Variations in infanticide and parental behavior in male mice due to prior intrauterine proximity to female fetuses: Elimination by prenatal stress. Physiol. Behav. 30, 675-681.

Wallen, K., Bielert, C., and Slimp, J. (1977). Foot clasp mounting in the prepubertal rhesus monkey: Social and hormonal influences. In S. Chevalier-Skolnikoff and F. E. Poirer (Eds.), Primate bio-social development, pp. 439-461. Garland Press, New York.

Wallen, K., Goldfoot, D. A., and Goy, R. W. (1981). Peer and maternal influences on the expression of foot-clasp mounting by juvenile male rhesus monkeys. Dev. Psychobiol. 14, 299-309.

Wang, H. W., Wysocki, C. J., and Gold, C. H. (1993). Induction of olfactory receptor sensitivity in mice. Science 260, 998-1000.

Ward, I. L. (1972). Prenatal stress feminizes and demasculinizes the behavior of males. Science 175, 82-84.

Ward, I. L. (1992). Sexual behavior: The product of perinatal hormonal and prepubertal social forces. In A. A. Gerall, H. Moltz, and I. L. Ward (Eds.), Handbook of Behavioral Neurobiology: Sexual Differentiation, Vol. 11, pp. 157-180. Plenum Press, New York.

Ward, I. L., and Weisz, J. (1984). Differential effects of maternal stress on circulating levels of corticosterone, progesterone, and testosterone in male and female rat fetuses and their mothers. Endocrinology 114, 1635-1644.

Wedekind, C., Seebeck, T., Bettens, F., and Paepke, A. J. (1995). MHC-dependent mate preferences in humans. Proc. Royal Soc. London-Ser. B: Biol. Sci. 260, 245-249.

Weller, L., and Weller, A. (1993). Human menstrual synchrony—A critical assessment. Neurosci. Biobehav. Rev. 17, 427-439.

Weller, P. A., Critcher, R., Goodfellow, P. N., German, J., and Ellis, N. A. (1995). The human Y chromosome homologue of XG: Transcription of a naturally truncated gene. Hum. Molec. Genet. 4, 859-868.

Whitam, F., Diamond, M., and Martin, J. (1993). Homosexual orientation in twins: A report on 61 pairs and three triplet sets. Arch. Sex. Behav. 22, 187-206.

Wilkins, A. S. (1995). Moving up the hierarchy: A hypothesis on the evolution of a genetic sex determination pathway.Bioessays 17, 71-77.

Wille, R, Borchers, D., and Schultz, W. (1987). Prenatal distress—A disposition for homosexuality. Conference Presentation International Academyfor Sex Research. Tutzing, FRG. [West Germany] (June 21-25).

Wolfe, J., Darling, S. M., Erickson, R. P., Craig, I. W., Buckle, V. J., Rigby, P. W. J., Willard, H. F., and Goodfellow, P. N. (1985). Isolation and characterization of an aiphoid centromeric repeat family from the human Y chromosome. J. Mol. Biol. 182, 477-485.

Wolfner, M. F. (1988). Sex-specific gene expression in somatic tissues of Drosophila melanogaster. Trends Genet. 4, 333-337.

Wu, X., and Haber, J. E. (1995). MATa donor preference in yeast mating-type switching: Activation of a large chromosomal region for recombination. Genes Dev. 9, 1922-1932.

Wysocki, C. J., and Beauchamp, G. K. (1984). Ability to smell androstenone is genetically determined. Proc. Natl. Acad. Sci. USA 81, 4899-4902.

Yntema, C. L. (1976). Effects of incubation temperatures on sexual differentiation in the turtle, Cheihydra serpentina J. J. Morphol. 150, 453-462.

Young, W. C. (1961). The hormones and mating behavior. In W. C. Young (Ed.), Sex and Internal Secretions, Vol. 2, pp. 1173-1239. The Williams & Wilkins Co., Baltimore.

Zhang, P., Rodriguez, H., and Mellon, S. H. (1995). Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: Implications for regulation of neurosteroidogenesis. Mol. Endocrinol. 9, 1571-1582.

Zinn, A. R., Alagappan, R. K., Brown, L. G., Wool, I., and Page, D. C. (1994). Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. Mol. Cell. Biol. 14, 2485-2492.

Zuccotti, M., and Monk, M. (1995). Methylation of the mouse Xist gene in sperm and eggs correlates with imprinted Xist expression and paternal X-inactivation. Nature Genet. 9, 316-320.

Zwingman, T., Erickson, R. P., Boyer, T., and Ao, A. (1995). Transcription of the sex-determining region genes Sry and Zfy in the mouse preimplantation embryo. Proc. Natl. Acad. Sci. USA 90, 814-817.