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An Interdisciplinary Journal on Sexual Health

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Sexual Revolution and Sexual Rights in Finland


Haavio-Mannila E & Kontula O.  Sexual Pleasures: Enhancement of Sex Life in Finland, 1971–1992. Hampshire. Dartmouth, 1995.

Haavio-Mannila E. & Kontula O. Sexual Trends in the Baltic Sea Area. Publications of the Population Research Institute, Series D41, Helsinki. The Population Research Institute, Family Federation of Finland, 2003.

Haavio-Mannila E, Kontula O. & Rotkirch A. Sexual Lifestyles in the Twentieth Century: A Research Study, Hampshire & New York: Palgrave, 2002.

Haavio-Mannila  E & Kontula O. Single and Double Sexual Standards in Finland, Estonia and St. Petersburg. Journal of Sex Research, 2003; 40: 36-49.

Hagman S. The Case of Legal Control over Homosexuality in Finland in Comparison to Other Nordic Countries. In O. Kontula (Ed.) Pleasure and Health by education, counselling and treatment. Proceedings of 2012 NACS conference in Helsinki (pp. 125-134). Helsinki.  The Finnish Association for Sexology (FIAS), 2012.

International Planned Parenthood Federation (IPPF) Sexual Rights


IPPF European Network (2006) Sexuality education in Europe – A reference guide.


Jaakkola M.  Finnish Attitudes toward Gay People. Janus 9.3.2001, 2003;  189-210.

Kontula O & Haavio-Mannila  E.  Sexual Pleasures: Enhancement of Sex Life in Finland, 1971–1992. Hampshire, Dartmouth, 1995.

Kontula O & Kosonen K.  Sexuality Changing from Privacy to the Open - A study of the Finnish press over the years from 1961 to 1991. Nordisk Sexologi, 1996; 14:34-47.

Kontula O. Implementation of Sexual Rights in Finland. In P.Alkio, E.Korhonen, M.Mattila (Eds.)Towards Sustainable Development – Policies and Practices: Finnish Achievements. (pp. 13-19). Helsinki. Väestöliitto - Family Federation of Finland, 2006.

Kontula O.  The role of pornography in media and in sex education. Tidsskrift for Norsk Psykologforening, 2008; 45:739-742.

Kontula O & Söderling I. Demographic Change and Family Policy Regimes. In C.Höhn, D.Avramov & I.E.Kotowska (Eds.) “People, Population Change and Policies. Lessons from the Population Policy Acceptance Study” Volume 2: Demographic Knowledge – Gender – Ageing (pp. 3-20). Dordrecht. Springer, 2008.

Kontula O & Haavio-Mannila E. Renaissance of Romanticism in the Era of Increasing Individualism. In J. Duncombe, K. Harrison, G. Allan & D. Marsden (Eds.) The State of Affairs: Explorations in Infidelity and Commitment) (pp. 79-102). New Jersey: Lawrence Erlbaum Associates, 2004.

Kontula O. & Haavio-Mannila E. Finland (Suomen Tasavalta) With up-dates by the original authors. In R.Francouer & R.Noonan (Eds.) The International Encyclopedia of Sexuality (pp. 381-411). New York: Continuum, 2003.

Kontula O. Reproductive health behaviour of young Europeans. Volume 2: The role of education and information. Population Studies No. 45. Council of Europe; Strasbourg: Council of Europe Publishing, 2004.

Kontula O. Between Sexual Desire and Reality: The Evolution of Sex in Finland. Helsinki. The Family Federation of Finland: The Population Research Institute D49/2009, 2009.

Kontula O. The evolution of sex education and student’s sexual knowledge in Finland in the 2000s. Sex Education, 2020; 10:373-386.

Lottes I & Kontula O. (Eds.). New Views on Sexual Health: The Case of Finland. D37/2000. The Population Research Institute, Helsinki. Family Federation of Finland, 2000.

Mustola K. Finland 1889 – 1999 a turbulent past. In J.Rydström, K. Mustola (Eds.) Criminally queer: homosexuality and criminal law in Scandinavia 1842–1999 (pp. 41-60). Amsterdam:Aksant, 2007. 

Niemi J. What we talk about when we talk about buying sex. Violence Against Women, 2010; 16:159-172.

World Health Organization (WHO)(2002) Sexual Rights


Sexocorporel in the Promotion of Sexual Pleasure

Karoline Bischof

SexuS Journal 2015, 1 (1): 033-043


Bischof-Campbell A. Zusammenhänge des sexuellen Erlebens von Frauen (Context of sexual experience in women) 2012. In preparation for publication, masters thesis, University of Zurich, Switzerland.

Chatton D, Desjardins JY, Desjardins L, Tremblay M

La sexologie clinique basée sur un modèle de santé sexuelle (Clinical sexology based on a model of sexual health)

Psychothérapies 2005; 25:3-19.

Desjardins JYApproche intégrative et sexocorporelle. (The integrative sexocorporel approach) Sexologies 1996; 5: 43-48.

Hansen JK, Balslev T. Hand activities in infantile masturbation: a video analysis of 13 cases.Eur J Paediatr Neurol. 2009; 13:508-10.

Komisaruk BR, Whipple B, Beyer C. Sexual pleasure. In: Kringelbach et al. Pleasures of the Brain. 2010; 168-177. Kringelbach ML, Berridge KC.Towards a functional neuroanatomy of pleasure and happiness.Trends Cogn Sci. 2009; 13:479-87.

Leknes S, Tracey I. A common neurobiology for pain and pleasure.Nat Rev Neurosci. 2008; 9:314-20.

Löken LS, Wessberg J, Morrison I, McGlone F, Olausson H.Coding of pleasant touch by unmyelinated afferents in humans. Nat Neurosci. 2009; 12:547-8.

Meston CM, Buss DM. Why humans have sex.Arch Sex Behav. 2007; 36:477-507.

Meston CM, Gorzalka BB. The effects of sympathetic activation on physiological and subjective sexual arousal in women. Behav Res Ther. 1995; 33:651-64.

Santarelli F.Ricerca sui modi eccitatori (Research on the arousal modes) 1987 Unpublished paper, Genova Ulrich-Lai YM e.a. Pleasurable behaviors reduce stress via brain reward pathways. PNAS 2010; 107:20529-34.

Yang ML, Fullwood E, Goldstein J, Mink JW. Masturbation in infancy and early childhood presenting as a movement disorder: 12 cases and a review of the literature.Pediatrics 2005; 116:1427-32.


Neurobiology of Sexual Desire

Suck Won Kim, Carlos H. Schenck, Jon E. GrantGihyun Yoon,Peter I. DosaBrian L. OdlaugLiana R.N. Schreiber, Thomas D. Hurwitz, James G. Pfaus 

Sexus Journal, 2015, 1(1): 044-076


Adams S, Heckard D, Hassell J, Uphouse L. Factors influencing fluoxetine-induced sexual dysfunction in female rats. Behav Brain Res 2012; 235: 73-81.

Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 1986; 9: 357-381.

Alexander GM, Packard MG, Hines M. Testosterone hasrewarding affective properties in male rats: implications for the biological basis of sexual motivation. Behav Neurosci 1994; 108: 424-428.

Allard J, Giuliano F. Central nervous system agents in the treatment of erectile dysfunction: how do they work?

Curr Urol Rep 2001; 2: 488-494.

Allen DL, Renner KJ, Luine VN. Pargyline-induced increase in serotonin levels: correlation with inhibition of lordosis in rats. Pharmacol Biochem Behav 1993; 45: 837-841.

Ang HH, Lee KL, Kiyoshi M. Sexual arousal in sexually

sluggish old male rats after oral administration of Eurycoma longifolia Jack. J Basic Clin Physiol Pharmacol 2004; 15: 303-309.

Ang HH, Ngai TH, Tan TH. Effects of Eurycoma longifolia

Jack on sexual qualities in middle aged male rats. Phytomedicine 2003; 10: 590-593.

Aston-Jones G, Smith RJ, Sartor GC, Moorman DE, Massi L, Tahsili-Fahadan P, et al. Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction. Brain Res 2010; 1314: 74-90.

Bai YJ, Li YH, Zheng XG, Han J, Yang XY, Sui N. Orexin A ttenuates unconditioned sexual motivation in male rats. Pharmacol Biochem Behav 2009; 91: 581-589.

Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S, et al. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 2003; 6: 743-749.

Balfour ME, Yu L, Coolen LM. Sexual behavior and sexassociated environmental cues activate the mesolimbic system in male rats. Neuropsychopharmacology 2004;9: 718-730.

Barley J, Ginsburg M, Greenstein BD, MacLusky NJ, Thomas PJ. An androgen receptor in rat brain and pituitary. Brain Res 1975; 100: 383-393.

Beach FA. Characteristics of masculine “sex drive.” In JonesMR, editor. Nebraska Symposium on Motivation. Volume 4. Lincoln: University of Nebraska Press; 1956. p. 1-31.

Becker JB. Direct effect of 17 beta-estradiol on striatum: sex  differences in dopamine release. Synapse 1990; 5: 157-164.

Bialy M, Kaczmarek L. c-Fos expression as a tool to search for the neurobiological base of the sexual behaviour of males. Acta Neurobiol Exp (Wars) 1996; 56: 567-577.

Bitran D, Hull EM. Pharmacological analysis of male rat sexual behavior. Neurosci Biobehav Rev 1987; 11: 365-389.

Bjarnadóttir TK, Fredriksson R, Schiöth HB. The generepertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. Gene 2005; 362: 70-84.

Blackburn JR, Pfaus JG, Phillips AG. Dopamine functions in appetitive and defensive behaviours. Prog Neurobiol 1992; 39: 247-279.

Blutstein T, Devidze N, Choleris E, Jasnow AM, Pfaff DW, Mong JA. Oestradiol up-regulates glutamine synthetase mRNA and protein expression in the hypothalamus and hippocampus: implications for a role of hormonally responsive glia in amino acid neurotransmission. J Neuroendocrinol 2006; 18: 692-702.

Boulware MI, Mermelstein PG. The influence of estradiol on nervous system function. Drug News Perspect 2005; 18: 631-637.

Boulware MI, Mermelstein PG. Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology. Steroids 2009; 74:608-613.

Bradley KC, Meisel RL. Sexual behavior induction of c-Fos in the nucleus accumbens and amphetamine-stimulated locomotor activity are sensitized by previous sexual experience in female Syrian hamsters. J Neurosci 2001; 21: 2123-2130.

Brown AD, Blagg J, Reynolds DS. Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today 2007; 12: 757-766.

Burgess PW, Gilbert SJ, Dumontheil I. Function and localization within rostral prefrontal cortex (area 10). Philos Trans R Soc Lond B Biol Sci 2007; 362: 887-899.

Caldwell JD, Jirikowski GF, Greer ER, Pedersen CA. Medial preoptic area oxytocin and female sexual receptivity. Behav Neurosci 1989; 103: 655-662.

Cantor JM, Binik YM, Pfaus JG. Chronic fluoxetine inhibits sexual behavior in the male rat: reversal with oxytocin. Psychopharmacology (Berl) 1999; 144: 355-362.

Carter CS, Williams JR, Witt DM, Insel TR. Oxytocin and social bonding. Ann N Y Acad Sci 1992; 652: 204-211.

Charron S, Koechlin E. Divided representation of concurrent goals in the human frontal lobes. Science 2010; 328:60-363.

Christoff K, Cosmelli D, Legrand D, Thompson E. Specifying the self for cognitive neuroscience. Trends Cogn Sci 2011; 15: 104-112.

Cicolin A, Tribolo A, Giordano A, Chiarot E, Peila E, Terreni A, et al. Sexual behaviors during sleep associated with polysomnographically confirmed parasomnia overlap disorder. Sleep Med 2011; 12: 523-528.

Clark JT. Sexual arousal and performance are modified by adrenergic-neuropeptide-steroid interactions. In: Bancroft J, editor. The pharmacology of sexual function and dysfunction. Amsterdam: Excerpta Medica; 1995. p. 55–68.

Clark JT, Smith ER. Clonidine suppresses copulatory behavior and erectile reflexes in male rats: lack of effect of naloxone pretreatment. Neuroendocrinology 1990; 51:57-364.

Conway MA, Pleydell-Pearce CW. The construction of autobiographical memories in the self-memory system. Psychol Rev 2000; 107: 261-288.

Cooper JR, Bloom FE, Roth RH. The biochemical basis of neuropharmacology. 6th ed. New York: Oxford University Press; 1991.

Damsma G, Pfaus JG, Wenkstern D, Phillips AG, Fibiger HC. Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion. Behav Neurosci 1992; 106: 181-191.

D'Argembeau A, Feyers D, Majerus S, Collette F, Van der Linden M, Maquet P, et al. Self-reflection across time: cortical midline structures differentiate between present and past selves. Soc Cogn Affect Neurosci 2008; 3: 244-252.

 de Jong TR, Veening JG, Olivier B, Waldinger MD. Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies. J Sex Med 2007; 4: 14-28.

Delgado PL, Brannan SK, Mallinckrodt CH, Tran PV, McNamara RK, Wang F, et al. Sexual functioning assessed in 4 double-blind placebo- and paroxetinecontrolled trials of duloxetine for major depressive disorder. J Clin Psychiatry 2005; 66: 686-692.

Di Sebastiano AR, Wilson-Pérez HE, Lehman MN, Coolen LM. Lesions of orexin neurons block conditioned place preference for sexual behavior in male rats. Horm Behav 2011; 59: 1-8.

Di Sebastiano AR, Yong-Yow S, Wagner L, Lehman MN,Coolen LM. Orexin mediates initiation of sexual behavior in sexually naive male rats, but is not critical for sexual performance. Horm Behav 2010; 58: 397-404.

Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Int J Impot Res 2004; 16: 51-59.

Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, Harning R. An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist. J Sex Med 2006; 3: 628-638.

Dominguez JM, Hull EM. Serotonin impairs copulation and attenuates ejaculation-induced glutamate activity in the medial preoptic area. Behav Neurosci 2010; 124: 554-557.

Dominguez JM, Gil M, Hull EM. Preoptic glutamate facilitates male sexual behavior. J Neurosci 2006; 26: 1699-1703.

Dominguez JM, Muschamp JW, Schmich JM, Hull EM. Nitric oxide mediates glutamate-evoked dopamine release in the medial preoptic area. Neurosci 2004; 125:203-210.

Dosa PI, Ward T, Walters MA, Kim SW. Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism. ACS Med Chem Lett 2013; 4(2): 254-258.

Du J, Lorrain DS, Hull EM. Castration decreases extracellular, but increases intracellular, dopamine in medial preoptic area of male rats. Brain Res 1998; 782:11-17.

Dulac C, Torello AT. Molecular detection of pheromone signals in mammals: from genes to behaviour. Nat Rev Neurosci 2003; 4: 551-562.

Edwards DA, Einhorn LC. Preoptic and midbrain control of sexual motivation. Physiol Behav 1986; 37: 329-35.

Erskine MS. Solicitation behavior in the estrous female rat: a review. Horm Behav 1989; 23(4): 473-502.

Everitt BJ. Sexual motivation: a neural and behavioural analysis of the mechanisms underlying appetitive and copulatory responses of male rats. Neurosci Biobehav Rev 1990; 14: 217-232.

Everitt BJ, Stacey P. Studies of instrumental behavior with sexual reinforcement in male rats (Rattus norvegicus): I. Effects of preoptic area lesions, castration, and testosterone. J Comp Psychol 1987; 101: 407-419.

Fadel J, Deutch AY. Anatomical substrates of orexindopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience 2002; 111: 379-387.

Fernández-Guasti A, Larsson K, Beyer C. Potentiative action of alpha- and beta-adrenergic receptor stimulation in inducing lordosis behavior. Pharmacol Biochem Behav985; 22: 613-617.

Ferry AT, Ongür D, An X, Price JL. Prefrontal cortical projections to the striatum in macaque monkeys: evidence for an organization related to prefrontal networks. J Comp Neurol 2000 25; 425: 447-470.

Fiber JM, Adames P, Swann JM. Pheromones induce c-fosin limbic areas regulating male hamster mating behavior. Neuroreport 1993; 4: 871-874.

Fibiger HC, Nomikos GG, Pfaus JG, Damsma G. Sexual behavior, eating and mesolimbic dopamine. Clin Neuropharmacol 1992; 15: 566A-567A.

Fiorino DF, Phillips AG. Facilitation of sexual behavior and enhanced dopamine efflux in the nucleus accumbens of male rats after D-amphetamine-induced behavioral sensitization. J Neurosci 1999a; 19: 456-463.

Fiorino DF, Phillips AG. Facilitation of sexual behavior inmale rats following d-amphetamine-induced behavioral sensitization. Psychopharmacology (Berl) 1999b; 142: 200-208.

Fiorino DF, Coury A, Phillips AG. Dynamic changes in nucleus accumbens dopamine efflux during the Coolidge effect in male rats. J Neurosci 1997; 17: 4849-4855.

Frankfurt M, McKittrick CR, Mendelson SD, McEwen BS. Effect of 5,7-dihydroxytryptamine, ovariectomy and gonadal steroids on serotonin receptor binding in rat brain. Neuroendocrinology 1994; 59: 245-250.

Genazzani AR, Bernardi F, Pluchino N, Giretti MS, Begliuomini S, Casarosa E, et al. Effect of tibolone administration on central and peripheral levels of allopregnanolone and beta-endorphin in female rats.

Menopause 2006; 13: 57-64. Georgescu M, Pfaus JG. Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors I. Behavioral effects of glutamate and its selective receptor agonists AMPA, NMDA and kainate. Pharmacol Biochem Behav 2006a; 83: 322-332.

Georgescu M, Pfaus JG. Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors. II. Behavioral effects of selective glutamate receptor antagonists AP-5, CNQX, and DNQX. Pharmacol Biochem Behav 2006b; 83: 333-341.

Georgescu M, Cyr D, Pfaus JG. AMPA/kainate receptors in the ventromedial hypothalamus mediate the effects of glutamate on estrus termination in the rat. Pharmacol Biochem Behav 2012; 102: 146-150.

Georgescu M, Sabongui C, Del Corpo A, Marsan L, Pfaus JG. Vaginocervical stimulation induces Fos in glutamate neurons in the ventromedial hypothalamus: attenuation by estrogen and progesterone. Horm Behav 2009; 56: 450-456.

Georgiadis JR, Kringelbach ML, Pfaus JG. Sex for fun: asynthesis of human and animal neurobiology. Nat RevUrol 2012; 9: 486-498.

Gilbert SJ, Dumontheil I, Simons JS, Frith CD, Burgess PW.Comment on "Wandering minds: the default network and stimulus-independent thought." Science 2007; 317: 43.

Gilbert SJ, Gonen-Yaacovi G, Benoit RG, Volle E, BurgessPW. Distinct functional connectivity associated with lateral versus medial rostral prefrontal cortex: a metaanalysis. Neuroimage 2010; 53: 1359-1367.

Gilbert SJ, Spengler S, Simons JS, Steele JD, Lawrie SM, Frith CD, et al. Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis. J Cogn Neurosci 2006; 18: 932-948.

Giuliano F, Allard J. Dopamine and sexual function. Int J Impot Res 2001; 13: S18-S28.

Giuliano F, Rampin O. Central neural regulation of penile erection. Neurosci Biobehav Rev 2000; 24: 517-533.

Gouvêa TS, Morimoto HK, de Faria MJ, Moreira EG, Gerardin DC. Maternal exposure to the antidepressant fluoxetine impairs sexual motivation in adult male mice. Pharmacol Biochem Behav 2008; 90: 416-419.

Graham MD, Pfaus JG. Differential effects of dopamine antagonists infused to the medial preoptic area on the sexual behavior of female rats primed with estrogen and progesterone. Pharmacol Biochem Behav 2012; 102: 532-539.

Gronemeyer H. Transcription activation by estrogen and progesterone receptors. Annu Rev Genet 1991; 25: 89-123.

Guarraci FA, Megroz AB, Clark AS. Effects of ibotenic acid lesions of the nucleus accumbens on paced mating behavior in the female rat. Behav Neurosci 2002; 116: 568-576.

Gusnard DA, Raichle ME, Raichle ME. Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci 2001; 2: 685-694.

Haber SN, Knutson B. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology 2010; 35: 4-26.

Hadley ME. Discovery that a melanocortin regulates  sexual functions in male and female humans. Peptides 2005; 26: 1687-1689.

Hansen S. Hypothalamic control of motivation: the medial preoptic area and masculine sexual behavior. In Sodersten P, editor. Behavioral neuroscience in Scandinavia. Scandinavian Journal of Psychology 1982; Suppl 1: 121-126.

Hansen S, af Hagelsrum LJ. Emergence of displacement activities in the male rat following thwarting of sexual behavior. Behav Neurosci 1984; 98: 868-883.

Hansen S, Köhler C, Goldstein M, Steinbusch HV. Effects of ibotenic acid-induced neuronal degeneration in the medial preoptic area and the lateral hypothalamic area on sexual behavior in the male rat. Brain Res. 1982; 239:213-232.

Hart BL. Medial preoptic-anterior hypothalamic lesions and sociosexual behavior of male goats. Physiol Behav 1986; 36: 301-305.

Heimer L, VanHoesen GW, Trimble MR, Zahm DS. Anatomy of Neuropsychiatry. Amsterdam, Netherlands: Elsevier Press; 2008. p. 45

Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, et al. Central serotonin and melanocortin pathways regulating energy homeostasis. Ann N Y Acad Sci 2003; 994: 169-174.

Hillegaart V, Alster P, Uvnäs-Moberg K, Ahlenius S.  Sexual motivation promotes oxytocin secretion in male rats. Peptides 1998; 19: 39-45.

Holstege G. Descending motor pathways and the spinal motor system: limbic and non-limbic components. Prog Brain Res 1991; 87: 307-421.

Holstege G, Bandler R, Saper CB. The emotional motor system. Prog Brain Res 1996; 107: 3-6.

Hoshina Y, Takeo T, Nakano K, Sato T, Sakuma Y. Axonsparing lesion of the preoptic area enhances receptivity and diminishes proceptivity among components of female rat sexual behavior. Behav Brain Res 1994; 61:197-204.

Hoyle CH, Stones RW, Robson T, Whitley K, Burnstock G. Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide-containing nerves. J Anat 1996; 188: 633-644.

Hughes AM, Everitt BJ, Herbert J. Comparative effects of preoptic area infusions of opioid peptides, lesions and castration on sexual behaviour in male rats: studies of instrumental behaviour, conditioned place preference and partner preference. Psychopharmacology (Berl) 1990; 102: 243-256.

Hull EM. Sex, drugs and gluttony: how the brain controls motivated behaviors. Physiol Behav 2011; 104: 173-177.

Hull EM, Dominguez JM. Getting his act together: roles of glutamate, nitric oxide, and dopamine in the medial preoptic area. Brain Res 2006; 1126: 66-75.

Hull EM, Rodriguez-Manzo G. Hormones, brain and behavior. In: Donald Pfaff D, editor. Male Sexual Behavior. 2nd ed., Vol 1. Amsterdam: Elsevier Press; 2009. p. 5-65

Hull EM, Du J, Lorrain DS, Matuszewich L. Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation. JNeurosci 1995; 15: 7465-7471.

Hull EM, Warner RK, Bazzett TJ, Eaton RC, Thompson JT, Scaletta LL. D2/D1 ratio in the medial preoptic area affects copulation of male rats. J Pharmacol Exp Ther 1989; 251: 422-427.

Humphries MD, Prescott TJ. The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward. Prog Neurobiol 2010; 90: 385-417.

Ito TY, Polan ML, Whipple B, Trant AS. The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status. J Sex Marital Ther 2006; 32: 369-378.

Johnston VS. The origin and function of pleasure. Cogn Emot 2003; 17: 167-179.

Ju G, Melander T, Ceccatelli S, Hökfelt T, Frey P. Immunohistochemical evidence for a spinothalamic pathway co-containing cholecystokinin- and galanin-like immunoreactivities in the rat. Neuroscience 1987; 20:439-456.

Kalivas PW. The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci 2009; 10: 561-572.

Kalivas PW, Barnes CD, editors. Limbic motor circuits and neuropsychiatry. Boca Raton, FL: CRC Press; 1993.

Kalivas PW, McFarland K. Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology (Berl) 2003; 168: 44-56.

Kalivas PW, McFarland K, Bowers S, Szumlinski K, Xi ZX, Baker D. Glutamate transmission and addiction to cocaine. Ann N Y Acad Sci 2003; 1003: 169-175.

Kalivas PW, Peters J, Knackstedt L. Animal models and brain circuits in drug addiction. Mol Interv 2006; 6: 339-344.

Kalivas PW, Volkow N, Seamans J. Unmanageable motivation in addiction: a pathology in prefrontalaccumbens glutamate transmission. Neuron 2005; 45: 647-650.

Kapur S, Craik FI, Jones C, Brown GM, Houle S, Tulving E. Functional role of the prefrontal cortex in retrieval of memories: a PET study. Neuroreport 1995; 6: 1880-1884.

Kato A, Sakuma Y. Neuronal activity in female rat preoptic area associated with sexually motivated behavior. Brain Res 2000; 862: 90-102.

Kia HK, Yen G, Krebs CJ, Pfaff DW. Colocalization of estrogen receptor alpha and NMDA-2D mRNAs in amygdaloid and hypothalamic nuclei of the mouse brain. Brain Res Mol Brain Res 2002; 104: 47-54.

Kippin TE, Sotiropoulos V, Badih J, Pfaus JG. Opposing roles of the nucleus accumbens and anterior lateral hypothalamic area in the control of sexual behaviour in the male rat. Eur J Neurosci 2004; 19: 698-704.

Kita I, Yoshida Y, Nishino S. An activation of parvocellular oxytocinergic neurons in the paraventricular nucleus in oxytocin-induced yawning and penile erection. Neuroscies 2006; 54: 269-275.

Kleitz-Nelson HK, Dominguez JM, Ball GF. Dopamine release in the medial preoptic area is related to hormonal action and sexual motivation. Behav Neurosci. 2010a; 124: 773-779.

Kleitz-Nelson HK, Dominguez JM, Cornil CA, Ball GF. Is sexual motivational state linked to dopamine release in the medial preoptic area? Behav Neurosci 2010b; 124: 300-304.

Koechlin E. Frontal pole function: what is specifically human? Trends Cogn Sci 2011; 15: 241.

Koechlin E, Hyafil A. Anterior prefrontal function and thelimits of human decision-making. Science 2007; 318:594-598.

Koechlin E, Basso G, Pietrini P, Panzer S, Grafman J. The role of the anterior prefrontal cortex in human cognition. Nature 1999; 399: 148-151.

Koechlin E, Ody C, Kouneiher F. The architecture of cognitive control in the human prefrontal cortex. Science 2003; 302: 1181-1185.

Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE. Excitation of ventral tegmental area dopamiergic and nondopaminergic neurons by orexins/hypocretins. J Neurosci 2003; 23: 7-11.

Kotz CM. Integration of feeding and spontaneous physical activity: role for orexin. Physiol Behav 2006; 88: 294-301.

Kouneiher F, Charron S, Koechlin E. Motivation and cognitive control in the human prefrontal cortex. Nat Neurosci 2009; 12: 939-945.

Kow LM, Harlan RE, Shivers BD, Pfaff DW. Inhibition of the lordosis reflex in rats by intrahypothalamic infusion of neural excitatory agents: evidence that the hypothalamus  contains separate inhibitory and facilitatory elements. Brain Res 1985; 341: 26-34.

Kow LM, Pfaff DW. Transmitter and peptide actions on hypothalamic neurons in vitro: implications for lordosis. Brain Res Bull 1988; 20: 857-861.

Kringelbach ML. The hedonic brain: a functional neuroanatomy of human pleasure. In: Kringelbach ML, Berridge KC, editors. Pleasures of the Brain. Oxford, UK: Oxford University Press; 2010.

Laan E, van Lunsen RH, Everaerd W. The effects of tibolo ne on vaginal blood flow, sexual desire and arousability in postmenopausal women. Climacteric 2001; 4: 28-41.

Landén M, Högberg P, Thase ME. Incidence of sexual side effects in refractory depression during treatment with citalopram or paroxetine. J Clin Psychiatry 2005; 66: 100-106.

Lesur A, Gaspar P, Alvarez C, Berger B. Chemoanatomic compartments in the human bed nucleus of the stria terminalis. Neuroscience 1989; 32: 181-194.

Landén M, Höberg P, Thase ME. Incidence of sexual side effects in refractory depression during treatment with citalopram or paroxetine. J Clin Psychiatry 2005; 66:100-106.

Levine B, Black SE, Cabeza R, Sinden M, Mcintosh AR, Toth JP, et al. Episodic memory and the self in a case of isolated retrograde amnesia. Brain 1998; 121: 1951-1973.

Liu YC, Sachs BD, Salamone JD. Sexual behavior in male rats after radiofrequency or dopamine-depleting lesions in nucleus accumbens. Pharmacol Biochem Behav 1998; 60: 585-592.

Li Y, Gao XB, Sakurai T, van den Pol AN. Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron 2002; 36: 1169-1181.

López HH, Ettenberg A. Exposure to female rats produces differences in c-fos induction between sexually-naïve and experienced male rats. Brain Res 2002; 947: 57-66.

Lorrain DS, Matuszewich L, Friedman RD, Hull EM. Extracellular serotonin in the lateral hypothalamic area is increased during the postejaculatory interval and impairs copulation in male rats. J Neurosci 1997; 17:9361-9366.

Lorrain DS, Riolo JV, Matuszewich L, Hull EM. Lateral hypothalamic serotonin inhibits nucleus accumbens dopamine: implications for sexual satiety. J Neurosci 1999; 19: 7648-7652.

Luo M, Fee MS, Katz LC. Encoding pheromonal signals in the accessory olfactory bulb of behaving mice. Science 2003; 299: 1196-11201.

Malmnäs CO. Monoaminergic influence on testosteroneactivated copulatory behavior in the castrated male rat. Acta Physiol Scand Suppl 1973; 395: 1-128.

Mas M, Rodriguez del Castillo A, Guerra M, Davidson JM,  Battaner E. Neurochemical correlates of male sexual behavior. Physiol Behav 1987; 41: 341-345.

Matuszewich L, Lorrain DS, Hull EM. Dopamine release in the medial preoptic area of female rats in response to hormonal manipulation and sexual activity. Behav Neurosci 2000; 114: 772-782.

 McCarthy MM. Frank A. Beach Award. Functional significance of steroid modulation of GABAergic neurotransmission: analysis at the behavioral, cellular, and molecular levels. Horm Behav 1995; 29: 131-140.

McFarland K, Kalivas PW. The circuitry mediating cocaine induced reinstatement of drug-seeking behavior. J Neurosci 2001; 21: 8655-8663.

McFarland K, Lapish CC, Kalivas PW. Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 2003; 23: 3531-3537.

McFarland K, Davidge SB, Lapish CC, Kalivas PW. Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. J Neurosci 2004; 24: 1551-1560.

McIntosh TK, Barfield RJ. Brain monoaminergic control of male reproductive behavior. I. Serotonin and the postejaculatory refractory period. Behav Brain Res 1984; 12:255-265.

Medina F, Siddiqui A, Scimonelli T, Fenske C, Wilson CA, Celis ME. The inter-relationship between gonadal steroids and POMC peptides, beta-endorphin and alpha-MSH, in the control of sexual behavior in the female rat. Peptides 1998; 19: 1309-1316.

Meisel RD, Sachs BD. The physiology of male reproduction. In: Knobil E, Neil JD, editors. The physiology of reproduction. Volume 2. New York: Raven Press; 1994. p. 3–105.

Melis MR, Argiolas A. Dopamine and sexual behavior. Neurosci Biobehav Rev 1995;19:19-38. Melis MR, Argiolas A. Central control of penile erection: a re-visitation of the role of oxytocin and its interaction with dopamine and glutamic acid in male rats. Neurosci Biobehav Rev 2011; 35: 939-955.

Ménard S, Coria-Avila GA, Gélèz H, Godfrey J, Sorochinski M, Pfaus JG. Activation of oxytocin and vasopressin neurons following the presentation of an odor associated with sexual reward in the male rat. Austin, TX: Ninth Annual Meeting of the Society for Behavioral Neuroendocrinology; 2005.

Mermelstein PG. Membrane-localised oestrogen receptor  alpha and beta influence neuronal activity through activation of metabotropic glutamate receptors. J Neuroendocrinol 2009; 21: 257-262.

Mermelstein PG, Micevych PE. Nervous system physiology regulated by membrane estrogen receptors. Rev Neurosci 2008; 19: 413-424.

Mermelstein PG, Becker JB, Surmeier DJ. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci 1996; 16: 595-604.

Meston CM, Gorzalka BB, Wright JM. Inhibition of subjective and physiological sexual arousal in women by clonidine. Psychosom Med 1997; 59: 399-407.

Mesulam MM. From sensation to cognition. Brain 1998;  21: 1013-1052.

Micevych PE, Mermelstein PG. Membrane estrogen receptors acting through metabotropic glutamate receptors: an emerging mechanism of estrogen action in brain. Mol Neurobiol 2008; 38: 66-77.

Miller SM, Lonstein JS. Dopaminergic projections to the medial preoptic area of postpartum rats. Neuroscience  2009; 159: 1384-1396.

Mogenson GJ, Jones DL, Yim CY. From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 1980; 14: 69-97.

Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J Clin Psychiatry 2001; 62: 10-21.

Moore KE, Looklingland KJ. Dopaminergic neuronal  systems in the hypothalamus. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: The fourth generation of progress. New York: Raven; 1995. p. 245–256.

Moore RY, Bloom FE. Central catecholamine neuron systems: anatomy and physiology of the norepinephrine and epinephrine systems. Annu Rev Neurosci 1979; 2: 113-168.

Muschamp JW, Dominguez JM, Sato SM, Shen RY, Hull EM. A role for hypocretin (orexin) in male sexual behavior. J Neurosci 2007; 27: 2837-2845.

Muschamp JW, Regina MJ, Hull EM, Winter JC, Rabin RA. Lysergic acid diethylamide and [-]-2,5-dimethoxy-4-methylamphetamine increase extracellular glutamate in rat prefrontal cortex. Brain Res 2004; 1023: 134-140.

Naess O. Characterization of the androgen receptors in the hypothalamus, preoptic area and brain cortex of the rat. Steroids 1976; 27: 167-185.

Naess O, Attramadal A, Aakvaag A. Androgen binding proteins in the anterior pituitary, hypothalamus, preoptic area and brain cortex of the rat. Endocrinology 1975; 96: 1-9.

Nappi RE, Ferdeghini F, Sampaolo P, Vaccaro P, De Leonardis C, Albani F, et al. Clitoral circulation in postmenopausal women with sexual dysfunction: a pilot randomized study with hormone therapy. Maturitas 2006; 55: 288-295.

Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, et al. Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci 2006; 26: 398-405.

Nieuwenhuys R, Voogd J, van Huijzen C. The human  central nervous system. 4th ed. Berlin, Germany: Springer; 2008. p. 289-322, 386-391, 934-940.

Nyberg L, McIntosh AR, Houle S, Nilsson LG, Tulving E.  Activation of medial temporal structures during episodic memory retrieval. Nature 1996; 380: 715-717.

Nyberg L, Tulving E, Habib R, Nilsson LG, Kapur S, Houle S, et al. Functional brain maps of retrieval mode and recovery of episodic information. Neuroreport 1995; 7: 249-252.

O'Donohue TL, Dorsa DM. The opiomelanotropinergic neuronal and endocrine systems. Peptides 1982; 3: 353-395.

Okuda J, Gilbert SJ, Burgess PW, Frith CD, Simons JS. Looking to the future: automatic regulation of attention between current performance and future plans. Neuropsychologia 2011; 49: 2258-2271.

Oosterom J, Nijenhuis WA, Schaaper WM, Slootstra J, Meloen RH, Gispen WH, et al. Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptors. J Biol Chem 1999; 274: 16853-16860.

Ottesen B, Gerstenberg T, Ulrichsen H, Manthorpe T, Fahrenkrug J, Wagner G. Vasoactive intestinal polypeptide (VIP) increases vaginal blood flow and inhibits uterine smooth muscle activity in women. Eur J Clin Invest 1983; 13: 321-324.

Paredes RG, Baum MJ. Role of the medial preoptic area/anterior hypothalamus in the control of masculine sexual behavior. Annu Rev Sex Res 1997; 8: 68-101.

Petri G, Wysocki CJ, Barnhart KT, Sondheimer SJ, Leyden JJ. Male axillary extracts contain pheromones that affect pulsatile secretion of luteinizing hormone and mood in women recipients. Biol Reprod 2003; 68(6): 2107-2113.

Pfaff DW. Drive: neurobiological and molecular mechanisms of sexual motivation. Cambridge, Massachusetts; The MIT Press; 1999.

Pfaff DW. Estrogens and brain function: neural analysis of a hormone-controlled mammalian reproductive behavior. Springer-Verlag, New York; 1980.

Pfaff D, Keiner M. Atlas of estradiol-concentrating cells in the central nervous system of the female rat. J Comp Neurol 1973; 151: 121-158.

Pfaff DW, Martin EM, Faber D. Origins of arousal: roles for  medullary reticular neurons. Trends Neurosci 2012; 35: 468-476.

Pfaff DW, McCarthy MM, Schwartz-Giblin S, Kow LM. Cellular and molecular mechanisms of female reproductive behaviors. In: Knobil E, Neill JD, editors. Physiology of reproduction: female reproductive behavior. New York: Raven Press; 1994. p. 107-220.

Pfaus JG. Neurobiology of sexual behavior. Curr Opin Neurobiol 1999b; 9: 751-758.

Pfaus JG. Pathways of sexual desire. J Sex Med 2009; 6: 1506-1533.

Pfaus JG. Revisiting the concept of sexual motivation. Annu Rev Sex Res 1999a; 10: 120-156.

Pfaus JG, Everitt BJ. The psychopharmacology of sexual behavior. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: the fourth generation of progress. New York: Raven Press; 1995. p. 743-757.

Pfaus JG, Giuliano F, Gelez H. Bremelanotide: An overview of preclinical CNS effects on female sexual function. J Sex Med 2007; 4: 269–279.

Pfaus JG, Heeb MM. Implications of immediate-early gene induction in the brain following sexual stimulation of female and male rodents. Brain Res Bull 1997; 44: 397-407.

Pfaus JG, Phillips AG. Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat. Behav Neurosci 1991; 105: 727-743.

Pfaus JG, Mendelson SD, Phillips AG. A correlational and factor analysis of anticipatory and consummatory measures of sexual behavior in the male rat. Psychoneuroendocrinology 1990a; 15: 329-340.

Pfaus JG, Ismail N, Coria-Avila GA. Sexual motivation. In Koob GF, Le Moal M, Thompson RF. Editors. Encyclopedia of behavioral neuroscience. Volume 3. Oxford: Academic Press; 2010. p. 201-209.

Pfaus JG, Damsma G, Wenkstern D, Fibiger HC. Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats. Brain Res 1995; 693: 21-30.

Pfaus JG, Shadiack A, Van Soest T, Tse M, Molinoff P. Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proc Natl Acad Sci U S A 2004; 101: 10201-10204.

Pfaus JG, Damsma G, Nomikos GG, Wenkstern DG, Blaha CD, Phillips AG, et al. Sexual behavior enhances central dopamine transmission in the male rat. Brain Res 1990b; 530: 345-348.

Pfaus JG, Kippin TE, Coria-Avila GA, Gelez H, Alfonso VM, Ismail N, et al. Who, what, where, when (and maybe even why)? How the experience of sexual reward connects sexual desire, preference, and performance. Arch Sex Behav 2012; 41: 31-62.

Pfaus JG, Tse TL, Werk CM, Chanda ML, Leblonde A, Harbour VL, et al. Enhanced synaptic responses in the piriform cortex associated with sexual stimulation in the  male rat. Neuroscience 2009; 164: 1422-1430.

Powell WS, Dominguez JM, Hull EM. An NMDA antagonist impairs copulation and the experience-induced enhancement of male sexual behavior in the rat. Behav  Neurosci 2003; 117: 69-75.

Powers JB, Newman SW, Bergondy ML. MPOA and BNST lesions in male Syrian hamsters: differential effects on copulatory and chemoinvestigatory behaviors. Behav Brain Res 1987; 23: 181-195.

Putnam SK, Du J, Sato S, Hull EM. Testosterone restoration  of copulatory behavior correlates with medial preoptic dopamine release in castrated male rats. Horm Behav  2001; 39: 216-224.

Putnam SK, Sato S, Riolo JV, Hull EM. Effects of testosterone metabolites on copulation, medial preoptic dopamine, and NOS-immunoreactivity in castrated male rats. Horm Behav 2005; 47: 513-522.

Raichle ME. The brain's dark energy. Sci Am 2010; 302: 44-49.

Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A 2001; 98: 676-682.

Ramírez OA, Carrer HF. Effect of estrogen and progesterone priming on the uptake and release of serotonin and noradrenaline from the ventromedial hypothalamus. Acta Physiol Lat Am 1982; 32: 313-319.

Ramnani N, Owen AM. Anterior prefrontal cortex: insights into function from anatomy and neuroimaging. Nat Rev Neurosci 2004; 5: 184-194.

Rivas FJ, Mir D. Effects of nucleus accumbens lesion on female rat sexual receptivity and proceptivity in a partner preference paradigm. Behav Brain Res 1990; 41:239-249.

Robinson TE, Berridge KC. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 1993; 18: 247-291.

Rodríguez-Manzo G, Fernández-Guasti A. Reversal of sexual exhaustion by serotonergic and noradrenergic agents. Behav Brain Res 1994; 62: 127-134.

Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res 2004; 16: 135-142.

Rössler AS, Pfaus JG, Kia HK, Bernabé J, Alexandre L, Giuliano F. The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat. Pharmacol Biochem Behav 2006; 85: 514-521.

Rupp HA, Wallen K. Relationship between testosterone   and interest in sexual stimuli: the effect of experience. Horm Behav 2007; 52: 581-589.

Ryan EL, Frankel AI. Studies on the role of the medial preoptic area in sexual behavior and hormonal response  to sexual behavior in the mature male laboratory rat. Biol Reprod 1978; 19: 971-983.

Sachs BD, Meisel RL. The physiology of male sexual behavior. In: Knobil E, Neil J, editors. The physiology of reproduction. New York: Raven Press; 1988. p. 1393-1485.

Sakamoto H, Satoh K, Oti T. Achieve orgasm? Oxytocin triggers orgasm in men. RSSD 2012; 1: 1-2.

Sakata JT, Gupta A, Gonzalez-Lima F, Crews D. Heterosexual housing increases the retention of courtship behavior following castration and elevates metabolic capacity in limbic brain nuclei in male whiptail lizards, Cnemidophorus inornatus. Horm Behav 2002a; 42: 263-273.

Sakata JT, Gonzalez-Lima F, Gupta A, Crews D. Repeated interactions with females elevate metabolic capacity in the limbic system of male rats. Brain Res 2002b; 936:27-37.

Sakuma Y. Differential control of proceptive and receptive components of female rat sexual behavior by the preoptic area. Jpn J Physiol 1995; 45: 211-228.

Sakuma Y. Neural substrates for sexual preference and motivation in the female and male rat. Ann N Y Acad Sci 2008; 1129: 55-60.

Sanderson NS, Le B, Zhou Z, Crews D. Preoptic neuronal nitric oxide synthase induction by testosterone is consistent with a role in gating male copulatory behavior. Eur J Neurosci 2008; 27: 183-190.

Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature 2005; 437: 1257-1263.

Saphier D, Feldman S. Electrophysiology of limbic forebrain and paraventricular nucleus connections. Brain Res Bull 1986; 17: 743-750.

Sato SM, Hull EM. The nitric oxide-guanosine 3',5'-cyclic monophosphate pathway regulates dopamine efflux in the medial preoptic area and copulation in male rats. Neuroscience 2006; 139: 417-428.

Sato S, Braham CS, Putnam SK, Hull EM. Neuronal nitric oxide synthase and gonadal steroid interaction in the MPOA of male rats: co-localization and testosteroneinduced restoration of copulation and nNOS immunoreactivity. Brain Res 2005; 1043: 205-213.

Schenck CH, Arnulf I, Mahowald MW. Sleep And sex: what can go wrong? A review of the literature on sleep related disorders and abnormal sexual behaviors and experiences. Sleep 2007; 30: 683-702.

Schober J, Weil Z, Pfaff D. How generalized CNS arousal strengthens sexual arousal (and vice versa). Horm Behav 2011; 59: 689-695.

Schulze HG, Gorzalka BB. Oxytocin effects on lordosis frequency and lordosis duration following infusion into the medial pre-optic area and ventromedial hypothalamus of female rats. Neuropeptides 1991; 18: 99-106.

Sesack SR, Grace AA. Cortico-Basal Ganglia reward  network: microcircuitry. Neuropsychopharmacology 2010;  35: 27-47. See pages 31-33.

Slavic I, Berglund H, Lindström P. Brain response to putative pheromones in homosexual men. Proc Natl Acad Sci USA 2005; 102(20): 7356-7361.

Slimp JC, Hart BL, Goy RW. Heterosexual, autosexual and social behavior of adult male rhesus monkeys with medial preoptic-anterior hypothalamic lesions. Brain Res 1978; 142: 105-122.

Steckelbroeck S, Jin Y, Oyesanmi B, Kloosterboer HJ, Penning TM. Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid. Mol Pharmacol 2004; 66: 1702-1711.

Stefanick ML, Davidson JM. Genital responses in noncopulators and rats with lesions in the medical preoptic area or midthoracic spinal cord. Physiol Behav 1987; 41: 439-444.

Succu S, Sanna F, Argiolas A, Melis MR. Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area. Neuropharmacology 2011; 61: 181-188.

Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis MR.Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin. Neuropharmacology 2007; 52: 1034-1043.

Sutcliffe JG, de Lecea L. The hypocretins: setting the arousal threshold. Nat Rev Neurosci 2002; 3: 339-349.

Swanson LW. Anatomy of the soul as reflected in the cerebral hemispheres: neural circuits underlying voluntary control of basic motivated behaviors. J Comp Neurol 2005; 493: 122-131.

Thomas Antérion C, Mazzola L, Laurent B. Autobiographic memory: phenomenological aspects, personal semantic knowledge, generic events and characters (one case of pure retrograde memory recovery). Neurophysiol Clin 2008; 38: 171-176.

Thorpe AJ, Cleary JP, Levine AS, Kotz CM. Centrally administered orexin A increases motivation for sweet pellets in rats. Psychopharmacology (Berl) 2005; 182: 75-83.

Tsujimoto S, Genovesio A, Wise SP. Frontal pole cortex: encoding ends at the end of the endbrain. Trends CognSci 2011;15: 169-176.

Tulving E. Episodic memory: from mind to brain. Annu Rev Psychol 2002; 53: 1-25.

Udry JR, Billy JO, Morris NM, Groff TR, Raj MH. Serum androgenic hormones motivate sexual behavior in adolescent boys. Fertil Steril 1985; 43: 90-94.

Uphouse L. Female gonadal hormones, serotonin, and sexual receptivity. Brain Res Brain Res Rev 2000; 33: 242-257.

Vega Matuszcyk J, Larsson K, Eriksson E. The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav 1998; 60(2): 527-532.

Vigdorchik AV, Parrish BP, Lagoda GA, McHenry JA, Hull  EM. An NMDA antagonist in the MPOA impairs copulation and stimulus sensitization in male rats. Behav Neurosci 2012; 126: 186-195.

Voisey J, Carroll L, van Daal A. Melanocortins and their receptors and antagonists. Curr Drug Targets 2003; 4: 586-597.

Wang J, Swann JM. The magnocellular medial preoptic nucleus I. Sources of afferent input. Neuroscience 2006; 141: 1437-1456.

Waldinger MD, Zwinderman AH, Olivier B. SSRIs and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram. J Clin Psychopharmacol 2001; 21: 556-560.

Warner LH. A study of sex behavior in the white rat by means of the obstruction method. Comparative Psychology Monograph 1927: 4.

Weiland NG, Wise PM. Estrogen alters the diurnal rhythm of alpha 1-adrenergic receptor densities in selected brain regions. Endocrinology 1987; 121: 1751-1758.

Wenkstern D, Pfaus JG, Fibiger HC. Dopamine transmission increases in the nucleus accumbens of male rats during their first exposure to sexually receptive female rats.Brain Res 1993; 618: 41-46.

Wilson CA, Thody AJ, Hole DR, Grierson JP, Celis ME. Interaction of estradiol, alpha-melanocyte-stimulating hormone, and dopamine in the regulation of sexual receptivity in the female rat. Neuroendocrinology 1991; 54: 14-22.

Wood RI. Thinking about networks in the control of male hamster sexual behavior. Horm Behav 1997; 32: 40-45.

Wood RI, Newman SW. Androgen and estrogen receptors coexist within individual neurons in the brain of the Syrian hamster. Neuroendocrinology 1995a; 62: 487-497.

Wood RI, Newman SW. The medial amygdaloid nucleus  and medial preoptic area mediate steroidal control of sexual behavior in the male Syrian hamster. Horm Behav 1995b; 29: 338-353.

Wood RI, Swann J. Neuronal integration of chemosensory and hormonal signals that control male sexual behavior. In: Wallen K, Schneider J, editors. Reproduction in context. Cambridge: MIT Press; 1999. p. 423-444.

Wood RI, Swann JM. The bed nucleus of the stria terminalis in the Syrian hamster: subnuclei and connections of the posterior division. Neuroscience 2005; 135: 155-179.

Wood RI, Brabec RK, Swann JM, Newman SW. Androgen and estrogen concentrating neurons in chemosensory pathways of the male Syrian hamster brain. Brain Res 1992; 596: 89-98.

Xiao L, Becker JB. Hormonal activation of the striatum and the nucleus accumbens modulates paced mating behavior in the female rat. Horm Behav 1997; 32: 114-124.

Young LJ, Wang Z. The neurobiology of pair bonding. Nat Neurosci 2004; 7: 1048-1054.

Zahm DS. Functional-anatomical implications of the nucleus accumbens core and shell subterritories. Ann N Y Acad Sci 1999; 877: 113-128.

Zemlan FP, Trulson ME, Howell R, Hoebel BG. Influence of p-chloroamphetamine on female sexual reflexes and brain monoamine levels. Brain Res 1977; 123: 347-356.

Altered States of Consciousness Occurring During Expanded Sexual Response (ESR) in the HumanFemale: Preliminary Definitions

 H. Ümit Sayin

SexuS Journal, 2015, 1(1): 077-088

Argiolas AMelis MR. The neurophysiology of the sexual cycle. Endocrinol Invest 2003; 26 (3 Suppl): 20-2.
Bodansky S, Bodansky V, Extended Massive Orgasm, CA: Hunter House Pub, 2000.

Brown ADBlagg JReynolds DS. Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today 2007; 12 (17-18): 757-66.

Chang J. The Tao of Love and Sex : The Ancient Chinese Way to Ecstasy. New York: Dutton, 1977.

Chang J. The Tao of the Loving Couple: True Liberation Through the Tao. New York: Dutton, 1983.  
Chia M, Chia M, Abrams M, Abrams RC. The Multi-Orgasmic Couple: Sexual Secrets Every Couple Should Know. New York: Harper One, 2002.

Chia M. Healing Love through the Tao: Cultivating Female Sexual Energy. New York: Destiny Books, 2005.

Fisher S. Understanding the Female Orgasm, London: Pelican Books, 1977.

Fisher S. The Female Orgasm: Psychology, Physiology, Fantasy. New York: Basic Books, 1973.

Giorgiadis RJ, Kortkaas R, Kuipers R, Neiuwenburg A, Pruim J,Simone Reinders AAT, Holstege G. Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women. Eur J Neurosci 2006; 24:3305-16.

Georgiadis RJ. Men versus women on Sexual Brain Function: Prominent differences during tactile genital stimulation, but not orgasm. Hum Brain Map 2009; 30(10):3089-101.

King R, Belsky J, Mah K, Binik YM. Are there different types of female orgasms? Arch Sex Behav 2010; 40(5):865-75.

Kocatürk A, Sayin U, Baş GY, Kocatürk C, Ocakçı AF. Sexual behavior patterns of Turkish females at two universities of İstanbul in 2011: Marmara and Bogaziçi universities pilot survey studies. 33rd NACS Conference 2011, Oslo-Norway, Nordic Association for Clinical Sexology 33rd Congress Abstract Book (33):15.

Komisaruk BR, Whipple B. Love as a sensory stimulation: Physiological Consequences of its deprivation and expression. Psych neuroendocrinology 1998; 8:927-944.
Komisaruk BR, Sansone G. Neural pathways mediating vaginal function: The vagus nerves and spinal cord oxytocin. Scandinavian J  Psych 2003; 44:241-250.

Komisaruk BR, Whipple B, Crawford A, Grimes S, Liu WC, Kalnin A, Mosier K. Brain activation during vagino-cervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by vagus nerves. Brain Res 2004; 1024:77-88.

Komisaruk BR, Whipple B. Functional MRI of the brain during orgasm in women.  Annu Rev Sex Res 2005; 16: 62-86.

Komisaruk BR, Beyer-Flores C, Whipple B. The Science of Orgasm, Baltimore: John Hopkins University Press, 2006.
Komisaruk BR, Wise NFrangos ELiu WCAllen KBrody S. Women's clitoris, vagina, and cervix mapped on the sensory cortex: fMRI evidence, J Sex Med 2011; 8(10):2822-30.

Krüger THHaake PHartmann USchedlowski MExton MS. Orgasm-induced prolactin secretion: feedback control of sexual drive? Neurosci Biobehav Rev 2002; 26(1):31-44.

Krüger THHartmann USchedlowski M. Prolactinergic and dopaminergic mechanisms underlying sexual arousal and orgasm in humans. World J Urol 2005;23(2):130-8.

Krüger THSchiffer BEikermann MHaake PGizewski ESchedlowski M. Serial neurochemical measurement of cerebrospinal fluid during the human sexual response cycle. Eur J Neurosci 2006; 24(12):3445-52.

Ladas AK, Whipple B, Perry JD, The G-Spot and Other Discoveries About Human Sexuality. New York: Henry Holt Co, 1982.

Magon NKalra S. The orgasmic history of oxytocin: Love, lust, and labor. Indian J Endocrinol Metab 2011;  Suppl 3:S156-61.

Mah K, Binik YM. The nature of orgasm: A critical review of major trends. Clin Psych Rev 2001; 6:823-56.

Mah K, Binik YM. Do all orgasms feel alike? Evaluating a two-dimensional model of the orgasm experience across gender and sexual context. J Sex Res 2002; 39:104-113.

Mah K, Binik YM. Are orgasms in the mind or the body? Psychosocial versus physiological correlates of orgasmic pleasure and satisfaction. J Sex & Marital Ther 2005; 31:187-200.

Mah K,  Binik YM.  The Orgasm Rating Scale. In T.D. Fisher, C.M. Davis, W.L. Yarber, & S.L. Davis (Eds.). Handbook of Sexuality-Related Measures (3rd ed.) (pp. 500-502). New York: Routledge, 2010.

Mamfurd J. Ecstasy through Tantra. Minnesota: Llewellyn Pub, 3rd ed.,  2005.

Masters W, Johnson V. Human Sexual Response. Missouri: Little Brown Company, 1966.

Michaels AM, Johnson P. Tantra for Erotic Empowerment. Minnesota: Llewellyn Pub, 2008.

Passie THartmann USchneider UEmrich HMKrüger TH. Ecstasy (MDMA) mimics the post-orgasmic state: impairment of sexual drive and function during acute MDMA-effects may be due to increased prolactin secretion. Med Hypotheses 2005; 64(5):899-903.

Rhodes R, Brauer AP, Brauer DJ. ESO Ecstasy Program, N.Y.: Grand Central Pub., 1991.

Sayin Ü, Ziyalar N, Kahya İ. ‘Orgasmic behavior in educated Turkish women’. Proc. 3rd European Academy of Forensic Science Triennal Meeting, Istanbul, Turkey, September 2003. Forensic Science International 2003; 136 (Suppl. 1):186. (a)

Sayin Ü, Ziyalar N, Kahya İ. ‘Sexual behavior in educated Turkish women’. Proc. 3rd European Academy of Forensic Science Triennal Meeting, Istanbul, Turkey, September 2003. Forensic Science International 2003; 136 (Suppl. 1):287. (b)

Sayin Ü. Derin Seks (Deep Sex), İstanbul: Klan Publications, 2010.

Sayin Ü, Ramstadius M.  Expanded Desire: The Main parameters and new definitions of enhanced and expanded sexual response (ESR).33rd NACS Conference 2011, Oslo-Norway, Nordic Association for Clinical Sexology 33rd Congress Abstract Book 2011; (33):21. (a)

Sayin Ü, Can G, Ramstadius M, Kocatürk A, Kahya İ. Desire in Turkish women: orgasmic behaviour patterns in 2240 educated Turkish women which improves with education. 33rd NACS Conference 2011, Oslo-Norway, Nordic Association for Clinical Sexology 33rd Congress Abstract Book 2011; (33):22. (b)

Sayin Ü, Ramstadius M, Kocatürk A. Pelvic floor muscle strength is correlated with attaining vaginal orgasms in human female as measured by Kegel Perineometer. 33rd NACS Conference 2011, Oslo-Norway, Nordic Association for Clinical Sexology 33rd Congress Abstract Book 2011; (33):22. (c)

Sayin Ü, Artırılmış Cinsel Doyum:ESR, Kadınlarda Ultra Orgazm (Expanded Sexual Response: ESR, Ultra Orgasm in Women), İstanbul: Okyanus Publications (in press), 2012.

Schwartz L, Schwartz B. The One Hour Orgasm. New York: St. Martin’s Griffin, 1999.

Stahl SM. The psychopharmacology of sex, Part 1: Neurotransmitters and the 3 phases of the human sexual response.  Clin Psychiatry 2001; 62(2):80-1.

Sukel K. Sex on the brain: Orgasms unlock altered consciousness. New Scientist 2011; 2812.  http://www.newscientist.com/article/mg21028124.600-sex-on-the-brain-orgasms-unlock-altered-consciousness.html?full=true.

Swartz LH. Absorbed states play different roles in female and male sexual response: hypothesis for testing. J Sex Marital Ther 1994; 20 (3) 244-53.

Taylor P. PhD Thesis: An Observational and Comparative Study of Practitioners of Expanded Orgasm: An Investigation of an Effective and Accessible Path to Transcendent States of Consciousness, Submitted in Partial Fulfillment of the Requirements for the Degree of Philosophy in Transpersonal Psychology, International University of Professional Studies, Maui, Hawaii, 2000.

Taylor P. Expanded Orgasm: Soar to Ecstasy at your Lover's Every Touch, Illinois: Sourcebooks, Casablanca, 2002.

Vatsyayana, Kama Sutra, Trans. by Burton R., London: Private, 1883. 

 Zdrok V. Anatomy of Pleasure, Philadelphia: Infinity Pub., 2004.